Deriva С МS — combination of adapalene (4th generation retinoid1) and clindamycin (antibiotic of a wide spectrum of activity1). Clindamycin penetrates the sebaceous hair follicle 75% faster when co-administered with adapalene1,2 Due to the form of a water gel, Deriva C MS is convenient to use, as it is quick is absorbed and does not leave stains on clothes It is enough to use 1 time per day to obtain a therapeutic effect Provides uniform distribution of the active substance and, as a result, increases effectiveness of treatment and reduces the risk of unwanted effects The number of inflamed areas of acne (papules) decreases by 44.6% already in the period between in the second and fourth weeks of treatment and by 93% in the 12th week of treatment* It has a double anti-inflammatory effect due to the retinoid adapalene and the antibiotic clindamycin Acts on the main links of acne pathogenesis Normalizes proliferation follicular epithelium and reduces the risk of new ones appearing microcomedones Clindamycin Reduces the number of microorganisms P.acne2 Has direct and indirect anti-inflammatory activity2 Prevents the appearance of new comedones (black and white spots)2 Adapalene Regulates the process of hyperkeratinization (excessive cell division in the middle of the hair follicle)2 Eliminates existing comedones (black and white spots)2 Prevents the appearance of new comedones (black and white spots)2 Has direct anti-inflammatory activity2 1 – Kalyuzhna L.D., Grechanska L.V., Petrenko A.V. Clinical effectiveness of new generation retinoids in the treatment of acne //Dermatovenerology cosmetology sex pathology 2 2015 2 – Gollnic H.P.M. From a new vision of the pathogenesis of acne to new approaches to treatment // Journal of the European Academy of Dermatology and Venereology – 2015
Who suits adults and children over 12 years old should not be used during pregnancy in case of unexpected pregnancy, treatment should be stopped 1 – Instructions for the medical use of the medicinal product Deriva C MS 2 – Instructions for medical use of the medicinal product Deriva water gel
About acne and treatment technology Acne (synonymous with "acne vulgaris") is an inflammatory skin disease, which mostly manifests itself on the face (in 99% of cases). It is less common on the neck (60%) and chest (15%). Seborrhea (excess secretion of sebum) is a frequent symptom of the disease. The clinical picture includes a spectrum of signs: from a mild form of comedones — with or without rare ones inflammatory lesions to an acute form of an aggressive disease with deep inflammation, nodes. To treat acne, you need: 1 Reduce the effect of androgens on the sebaceous gland 3 Reduce inflammation 2 Normalize the hyperkeratinization process (excessive cell division in the middle of the hair follicle) 4 Reduce the number of microorganisms P. acne 1 Reduce the effect of androgens on the sebaceous gland 2 Normalize the hyperkeratinization process (excessive cell division in the middle of the hair follicle) 3 Reduce inflammation 4 Reduce the number of microorganisms P. acne 1 – European Academy of Dermatology and Venereology European evidence-based (S3) acne treatment standards. JEADV 2012, 26 (Suppl. 1), 1–29 2 – Bolotna L.A. The use of synthetic retinoids of the new generation for the external treatment of acne // Ukrainian journal of dermatology, venereology, cosmetology – 2014-№2 (53).
Application method *Contraindications according to the instructions Derivative C MS – for the main treatment of inflammatory rashes. Apply the gel in a thin layer on clean, dry skin in places of rashes once a day at night. During the first weeks of treatment, exacerbation of the acne process is possible due to the effect of the active substance on lesions that were not visible before. In this case, treatment should not be stopped. The course of treatment is determined by the doctor. Deriva water gel — for reliable acne control after the main treatment of Deriva C MS. Apply the gel in a thin layer on clean, dry skin in places of rashes once a day at night. For maintenance therapy, it is optimal to use 2-3 times a week for up to 6-12 months. During the first weeks of treatment, exacerbation of the acne process is possible due to the effect of the active substance on lesions that were not visible before. In this case, treatment should not be stopped. 1 – Instructions for medical use of the medicinal product Deriva C MS 2 – Instructions for medical use of the medicinal product Deriva water gel 3 – Kokhan M.M., Keniksfest Y.V., Polishchuk O.I. Actual approaches to the external therapy of acne. Herald of Dermatology and Venereology. No. 2, 2016, p. 83-87. *Contraindications according to the instructions
Additional Information What is the cause of pimples (acne)? The leading role belongs to the increased level of hormones (androgens), which is determined by the hereditary characteristics of a person. An excess of these hormones leads to a malfunction of the sebaceous glands.2 What is the difference between pimples, blackheads and acne? There is no difference between these terms, pimples and blackheads are unofficial names for the rash used by ordinary people, acne is a medical term that describes a rash on the skin associated with sebaceous hair follicle damage. Who most often has pimples (acne)? Pimples (acne) affect from 70 to 90% of teenagers and young people aged 12 to 24.6 Which skin surfaces are most often affected by acne? 99% – face5 60% – back5 15% – breast5 From what age can you use Deriva C MS? Derivative C MS is approved for use from the age of 121, since it is at this age that skin problems begin. How does diet and exercise affect my breakouts (acne)? Exercise and a healthy diet can greatly improve the health of your skin. Exercising increases blood circulation in your body and delivers vital nutrients to your skin that help keep it healthy. Before you exercise, make sure your skin is clean and you’re wearing the right workout clothes to help keep your skin dry and dirt-free. Always take a warm shower after exercising and allow your body to cool down and dry before getting dressed3. You can improve your skin with diet by avoiding foods that cause breakouts and replacing carbs, sugars and starches with lean proteins, fruits and vegetables.4 What types of acne are there? Black spot (open comedone) White dot (open comedone) Papule Pustule How should I wash my face? Sticking to a consistent skin care routine can be difficult, but it’s essential in fighting acne. Talk to your dermatologist about your skin care regimen. It usually includes washing regularly7, getting enough sleep8, eating right, exercising9,10 and using the right skin care products11. Acne treatment and prevention begins with a regular skin care routine11. So you should choose an effective care for you and follow it every day.12 Is it possible to "squeeze pimples"? Hands harbor sebum and bacteria, and touching the skin and squeezing pimples will only sink the bacteria deeper and can increase the risk of acne scarring (acne)13. How do sleep and stress affect pimples (acne)? Sleep helps keep your immune system strong and helps relieve stress and anxiety.14 Stress is a huge acne trigger, so better stress management can help you avoid acne and improve skin health9 How does solar insolation affect pimples (acne)? Did you know that a tan on your skin is actually your body’s response to damage?15 Increasing time in the sun can lead to premature skin aging. Sun-damaged skin can look dry and wrinkled. Damaged skin can also increase your chance of getting skin cancer!16 Use sunscreen, regardless of the season, your age, or skin type.17 Broad-spectrum SPF 30 is ideal for most skin types, and some body moisturizers even contain SPF 30.18 How to shave if I have pimples (acne)? It is better to be delicate when caring for facial hair. Choose a gentle shaving cream and let it sit on your face for at least a minute before shaving.19 Shave in the direction of hair growth to reduce irritation.20 Don’t be afraid to use an electric razor . They won’t provide a perfectly clean shave like a razor blade, but electric razors are much less irritating to the skin. If you use a traditional razor, be sure to change your blade every 5-7 shaves.19 After shaving, wash your face with cool water to help reduce irritation and wash away excess shaving products from your skin.19 How to use cosmetics with pimples (acne)? Healthy skin is clean skin. Regarding make-up: it is better not to abuse it. Avoid products containing aromatic oils. Use makeup products that are “non-comedogenic” and don’t clog pores7. Use alcohol-free moisturizers. And don’t forget to keep your makeup brushes clean!21 Sources and literature 1 – Instructions for the medical use of the medicinal product Deriva C MS. 2 – Bolotnaya L.A. The use of synthetic retinoids of the new generation for the external treatment of acne // Ukrainian journal of dermatology, venereology, cosmetology – 2014-№2 (53). 3 – American Academy of Dermatology, 5 Dec. 2013, “Dermatologists Share Home Remedies for Dry Skin.” Employment and Benefits, https://www.aad.org/public/everyday-care/skin-care-basics/dry/dermatologists-tips-relieve-dry-skin 4 – Bowe, W. P., Joshi, S. S., & Shalita, A. R. (2010). Diet and acne. Journal of the American Academy of Dermatology, 63(1), 124-141 5 – European Evidence-based (S3) Guideline for the Treatment of Acne (ICD L70.0) Update 2016. 6 – Я.Ф. Кутасевич Акне: непростая задача в практике клинициста //Медична газета «Здоров’я України 21 сторіччя» №6 (379), березень 2016 р. 7 – Matsuoka Y, Yoneda K, Sadahira C, Katsuura J, Moriue T, Kubota Y. Effects of skin care and makeup under instructions from dermatologists on the quality of life of female patients with acne vulgaris. The Journal of Dermatology. 2006;33(11):745-752. 8 – Hirotsu, C., Albuquerque, R. G., Tufik, S., & Andersen, M. L. SLEEP AND DERMATOLOGY. 9 – Chiu A, Chon SY, Kimball AB. The response of skin disease to stress: changes in the severity of acne vulgaris as affected by examination stress. Archives of Dermatology. 2003;139(7):897-900. 10 – Pedersen BK, Saltin B. Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases. Scandinavian Journal of Medicine & Science in Sports. 2015;25:1-72. 11 – Del Rosso, J. Q., Gold, M., Rueda, M. J., Brandt, S., & Winkelman, W. J. Efficacy, Safety, and Subject Satisfaction of a Specified Skin Care Regimen to Cleanse, Medicate, Moisturize, and Protect the Skin of Patients Under Treatment for Acne Vulgaris. The Journal of Clinical and Aesthetic Dermatology, 2015;8(1), 22–30. 12 – Baldwin HE. Tricks for improving compliance with acne therapy. Dermatologic Therapy. 2006;19(4):224-236. 13 – Tan, J. K. L., & Bhate, K. A global perspective on the epidemiology of acne. British Journal of Dermatology, 2015;172, 3-12. 14 – Poli F, Dreno B, Verschoore M. An epidemiological study of acne in female adults: results of a survey conducted in France. Journal of the European Academy of Dermatology and Venereology. 2001;15(6):541-545. 15 – Sunscreen and Prevention of Skin Aging. Annals of Internal Medicine. 2013;158(11). Seité S, Fourtanier AM. The benefit of daily photoprotection. Journal of the American Academy of Dermatology. 2008;58(5). 16 – American Academy of Dermatology. (2018). Sunscreen FAQs [webpage]. https://www.aad.org/media/stats/prevention-and-care/sunscreen-faqs Accessed 22 September 2018. 17 – Sunscreen and Prevention of Skin Aging. Annals of Internal Medicine. 2013;158(11). Seité S, Fourtanier AM. The benefit of daily photoprotection. Journal of the American Academy of Dermatology. 2008;58(5). 18 – Farberg, A. S., Glazer, A. M., Rigel, A. C., White, R., & Rigel, D. S. (2017). Dermatologists’ perceptions, recommendations, and use of sunscreen. JAMA dermatology, 153(1), 99-101. 19 – American Academy of Dermatology (2018. Tips for men: How to shave. [webpage]. Accessed 22 September 2018 20 – Elsner, P. (2012). Overview and trends in male grooming. British Journal of Dermatology, 166, 2-5. 21 – American Academy of Dermatology (2018). I have acne. Is it ok to wear makeup? ([webpage]. https://www.aad.org/public/diseases/acneand-rosacea/makeup-with-acne. Accessed 22 September 2018
About the company Glenmark Pharmaceuticals Ltd. is an international pharmaceutical company whose activity is based on scientific research and development of innovative medicines. The company operates in more than 50 countries. Globally, the company focuses on the following therapeutic areas: oncology, dermatology and respiratory diseases. The company is represented in the segment of reproduced drugs, specialized drugs and in the over-the-counter (OTC) segment. The company is among the TOP 80 pharmaceutical and biotechnology companies in the world in terms of revenue (SCRIP 100 rating, 2019). More details are available at www.glenmarkpharma.com. Pharmacovigilance is an extremely important aspect of Glenmark’s activity. We pay great attention to the safety and effectiveness of our medicines. If you have experienced any adverse reactions after using our drug, we ask you to report it by visiting our pharmacovigilance page https://glenmarkpharma.ua/farmakonahlyad or by sending us an email to Safety.Ukraine@glenmarkpharma.com to report adverse reactions or lack of effectiveness. Your comments and observations will help us ensure the safety and quality of our products. Thank you for your cooperation in keeping patients safe.
